Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release
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Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release.
Parathyroid hormone (PTH) is positively coupled to the generation of cAMP via its actions on the PTH1R and PTH2R receptors. Renin secretion from juxtaglomerular (JG) cells is stimulated by elevated intracellular cAMP, and every stimulus that increases renin secretion is thought to do so via increasing cAMP. Thus we hypothesized that PTH increases renin release from primary cultures of mouse JG ...
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21 22 Corresponding author: 23 Prof. William H. Beierwaltes, Ph.D. 24 Senior Research Scientist, 25 Dept. Internal Medicine, 26 Hypertension and Vascular Research Div., 27 Henry Ford Hospital 28 7121 E&R Bldg., 2799 W. Grand Blvd., Detroit, MI 48202 29 313-916-7494, FAX 313-916-5284, [email protected] 30 31 32 33 34 35 Articles in PresS. Am J Physiol Endocrinol Metab (May 29, 2012). doi:10.1152...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2012
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00269.2012